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Introduction
Francisella tularensis is a small, weakly staining,
gram-negative cocco-bacillus, 0.2 by 0.2 to 0.7 um in
size. It is non-motile, with a thick capsule, and is
a facultative intracellular parasite: it undergoes phagocytosis
but evades intracellular killing. Biovar F. tularensis,
tularensis is found mainly in North America. Biovar
F. tularensis, palaearctica is found primarily in Europe
and Russia.
Clinical Manifestations of Aerosol Tularemia
Infection
The most common forms of tularemia resulting from a
BW (aerosol) attack will be typhoidal and pneumonic.
Tularemic meningitis, gastrointestinal disease, and
bacterial endocarditis may result from these forms of
infection. However, these same complications could result
from typhoidal or pneumonic forms as well. The incubation
period is 2-5 days.
Symptoms of the Pneumonic form include fever, headache,
muscle pain, difficulty to breath, short of breath,
cough, and pleural pains. X-ray will reveal spotted
infiltrates in lungs, lobular pneumonia, and pleural
exudation. Symptoms of the Typhoidal form include fever
without visible foci on skin and without lymphadenopathy
- this form of disease could be very difficult to diagnose
without collecting a thorough anamnesis.
Diagnosis and Treatment
Presenting Syndromes: Lymphadenitis and ulcers for ulceroglandular.
Influenza like symptoms for Aerosol exposure: High Fever,
Aches and Pains, enlarged lymph nodes.
Diagnostic Samples: Respiratory Secretions (pharyngeal
wash, sputum), Blood (inconsistent recovery from blood)
Differential Diagnosis : Anthrax, Plague, Q fever
Isolation/Decon Precautions : Standard precautions
as person-to-person transmission has not been documented.
Therapy for Inhalational tularemia: From CDC guidelines
and Consensus Statement on Tularemia (JAMA, June 6,
2001, v285 (21)).
For mass-casualty settings, ciprofloxacin or doxycycline
may be used.
Ciprofloxacin 500 mg Oral 2x/day (Peds: 15mg/kg oral
2x/day dosing up to 1 Gm/day)
Doxycycline 100 mg Oral 2x/day (14-21 days) (Peds: 100
mg Oral 2x/day; <45 kg, 2.2mg/kg oral2x/day)
Note: For single cases or controlled casualty settings,
streptomycin or gentamycin are preferred and should
be given for 10 days to avoid relapse.
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